Abstract #3449

Altered microstructural integrity of the white matter tracts in strabismus: A systematic tract-specific analysis over the whole brain

Hsien-Te Su¹, Tzu-Hsun Tsai², Yao-Chia Shih³, Yu-Shiang Tzeng⁴, Chien-Chung Chen⁴, and Wen-Yih Isaac Tseng^1,5

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei City, Taiwan, ²Department of ophthalmology, National Taiwan University Hospital, Taipei City, Taiwan, ³Institute of Biomedical Engineering,National Taiwan University, Taipei City, Taiwan, ⁴Department of Psychology, National Taiwan University College of Science, Taipei City, Taiwan, ⁵Molecular Imaging Center, National Taiwan University, Taipei City, Taiwan

To investigate whether the white matter tracts are altered in patients with strabismus, we used diffusion spectrum imaging to measure microstructural property of 78 major white matter tracts, and compared the property between 12 patients with strabismus adults and 24 matched controls. As compared to the controls, patients showed differences with large effect sizes in the left vertical occipital fasciculus, callosal fibers to bilateral precuneus, callosal fibers to bilateral inferior parietal lobules, and the left superior longitudinal fasciculus I. The altered white matter tracts support the hypothesis of underlying microstructural changes of the visual pathways in strabismus.

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