Abstract #3452

Prediction of the development of distant metastases from nasopharyngeal carcinoma using Diffusion-Weighted Imaging

Qi Yong Ai¹, Ann D. King¹, Benjamin King Hong Law¹, Lok Yiu Sheila Wong¹, Kunwar S. Bhatia¹, David Ka Wai Yeung², and Brigette B.Y. Ma²

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong, ²Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong

This study evaluated pre-treatment diffusion weighted imaging of primary nasopharyngeal carcinoma for the prediction of patients at risk of distant metastases, based on long-term follow-up for at least 5 years. Analysis was performed of ADC parameters using histogram analysis (ADC_mean, ADC_skewness and ADC_kurtosis), together with stage and volume of the primary tumour and nodes. Multivariate analysis showed pre-treatment ADCskewness, T stage and nodal volume were significant ( p =0.026, 0.022 and 0.005, respectively), distant metastases being more likely in patients with tumours with ADC values skewed toward the higher ADC range, and higher T stage and nodal volume.

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