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Abstract #3452

Prediction of the development of distant metastases from nasopharyngeal carcinoma using Diffusion-Weighted Imaging

Qi Yong Ai1, Ann D. King1, Benjamin King Hong Law1, Lok Yiu Sheila Wong1, Kunwar S. Bhatia1, David Ka Wai Yeung2, and Brigette B.Y. Ma2

1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong, 2Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong

This study evaluated pre-treatment diffusion weighted imaging of primary nasopharyngeal carcinoma for the prediction of patients at risk of distant metastases, based on long-term follow-up for at least 5 years. Analysis was performed of ADC parameters using histogram analysis (ADCmean, ADCskewness and ADCkurtosis), together with stage and volume of the primary tumour and nodes. Multivariate analysis showed pre-treatment ADCskewness, T stage and nodal volume were significant ( p =0.026, 0.022 and 0.005, respectively), distant metastases being more likely in patients with tumours with ADC values skewed toward the higher ADC range, and higher T stage and nodal volume.

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