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Abstract #3482

Intravoxel incoherent motion diffusion weighted imaging in evaluating the radio-sensitivity of nasopharyngeal carcinoma xenografts

Youping Xiao1, Yunbin Chen1, Jianji Pan2, Dechun Zheng1, Xiang Zheng1, and Ying Chen1

1Radiology, Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of, 2Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of

In this present study, by applying the special mouse coil(4 channel), IVIM-DWI with 14 b-factors(0~1000s/mm2) was successfully conducted on nude mice with different radio-sensitive NPC xenografts(CNE-1 and CNE-2) during the course of fractional radiations. The IVIM-DWI parameters of xenografts were found to change characteristically after fractional radiations and were significantly different between different radio-sensitive NPC xenografts, and their corresponding changes also behaved significant correlations with the pathological features of NPC xenografts. Thus, it is suggested IVIM-DWI parameters be valuable in evaluating the micro-structures and radio-sensitivity of NPC xenografts.

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