Abstract #3482

Intravoxel incoherent motion diffusion weighted imaging in evaluating the radio-sensitivity of nasopharyngeal carcinoma xenografts

Youping Xiao¹, Yunbin Chen¹, Jianji Pan², Dechun Zheng¹, Xiang Zheng¹, and Ying Chen¹

¹Radiology, Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of, ²Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of

In this present study, by applying the special mouse coil(4 channel), IVIM-DWI with 14 b-factors(0~1000s/mm²) was successfully conducted on nude mice with different radio-sensitive NPC xenografts(CNE-1 and CNE-2) during the course of fractional radiations. The IVIM-DWI parameters of xenografts were found to change characteristically after fractional radiations and were significantly different between different radio-sensitive NPC xenografts, and their corresponding changes also behaved significant correlations with the pathological features of NPC xenografts. Thus, it is suggested IVIM-DWI parameters be valuable in evaluating the micro-structures and radio-sensitivity of NPC xenografts.

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