Abstract #3486

Measuring diffusion time dependence of pseudo-diffusion using flow compensated pulsed and oscillating gradient sequences

Dan Wu¹ and Jiangyang Zhang^1,2

¹Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, ²Radiology, New York University School of Medicine, New Yourk, NY, United States

Intravoxel incoherent motion (IVIM) in the capillaries reflects capillary geometry and flow velocity, which may be probed by diffusion MRI measured at varying diffusion times. In this study, we employed flow-compensated pulsed and oscillating gradient sequences to investigate the diffusion time dependence of pseudo-diffusion in the mouse brain with diffusion times ranging from 2.5 ms to 40 ms. We used a simplified IVIM model to characterize the pseudo-diffusion compartment and flow compartment based on the relation between capillary segments and diffusion time/distance. Our results clearly demonstrated diffusion time dependence and suggested that the pseudo-diffusion fraction increased with increasing diffusion time.

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