Abstract #3485

Multi-Center Validation of an Acetone-D2O Quantitative Diffusion Phantom

Xiaoke Wang¹, Samir D Sharma², Mustafa R Bashir³, Jean H Brittain², Jean Shaffer³, Takeshi Yokoo⁴, Qing Yuan⁴, Scott B Reeder^1,2,5,6,7, and Diego Hernando²

¹Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Radiology, Duke University, Durham, NC, United States, ⁴Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁶Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

A recently proposed acetone-D₂O phantom, which has ADC tunable over the entire physiological range, has shown promise for the development and quality assurance of quantitative diffusion MRI. In this study, this phantom was shipped between three sites with different MRI vendors to demonstrate consistent diffusion quantification across imaging protocols, platforms, and field strengths. The results demonstrated consistent ADC measurements across sites/vendors, field strength, choice of b-values, intra-exam and inter-exam repetition. In conclusion, the acetone-D₂O phantom is a promising tool for future multi-center validation and quality assurance of quantitative diffusion MRI techniques.

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