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Abstract #3488

Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging for Monitoring the Early Response to ZD6474 from Nasopharyngeal Carcinoma in Nude Mouse

Yong Zhang1 and Yanfen Cui2

1GE Healthcare China, Shanghai, China, Shanghai, China, People's Republic of, 2Department of Radiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, People's Republic of

This study was to investigate the feasibility of IVIM DWI to evaluate the early therapeutic effects of ZD6474 upon human NPC xenografts in nude mouse. NPC mice underwent IVIM DWI at baseline and after 1, 3, and 7 days of treatment. In the treated group, the f and D* decreased significantly on day 1 while the ADC and D were significantly higher from day 3 compared with the control group, demonstrating that IVIM DWI is sensitive to detect the ZD6474-induced changes in human NPC nude mouse, and the D* and f parameters could predict early response to anti-angiogenic treatment.

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