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Abstract #3491

Using intravoxel incoherent motion MR imaging to measure renal diffusion and perfusion in contrast-induced acute kidney injury

Bin Zhang1, Long Liang1, Yuhao Dong1, Kannie W.Y. Chan2, Guanshu Liu2, Changhong Liang1, and Shuixing Zhang1

1Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, Guangzhou, China, People's Republic of, 2Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore 21287, USA, Baltimore, AL, United States

Contrast-induced acute kidney injury (CI-AKI) is a common iatrogenic event caused by the injection of iodinated contrast agent, and remains the third major source of in-hospital acquired acute renal failure.The objective of our study is to examine the feasibility of using Intravoxel Incoherent Motion (IVIM) MRI to simultaneously measure the pathological changes in kidney diffusion and perfusion in the course of CI-AKI. Our results showed that the kidney perfusion and diffusion as measured by IVIM are well-correlated with those measured using conventional methods, indicating IVIM MRI can be used as an effective tool for the diagnosis and staging of CI-AKI.

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