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Abstract #3490

Diffusion Kurtosis Metrics as Biomarker of Fibre Maturity

Grinberg Farida1,2, Ivan I. Maximov1,3, Ezequiel Farrher1, Irene Neuner1,4,5, Eileen Oberwelland6,7, Kerstin Konrad5,6,8, and N. Jon Shah1,2,5

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Juelich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3Experimental Physics III, TU Dortmund University, Dortmund, Germany, 4Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 5JARA - BRAIN - Translational Medicine, Aachen, Germany, 6Institute of Neuroscience and Medicine – 3, Forschungszentrum Jülich GmbH, Juelich, Germany, 7Translational Brain Research in Psychiatry and Neurology, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany, 8Child Neuropsychology Section, Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany

Diffusion tensor imaging has enabled the examination of white matter connectivity and microstructural changes across the lifespan. However, the detection of subtle microstructural changes during typical brain maturation still remains challenging. Recently, diffusion kurtosis imaging has attracted much attention as an efficient method for characterising non-Gaussian water diffusion in brain tissue. Here, we tested whether diffusion kurtosis imaging can extend our knowledge of changes in brain tissue microstructure related to normal brain development. We showed that diffusion kurtosis imaging provides useful biomarkers sensitive to the level of maturity in association, projection and commissural fibres.

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