Abstract #3497

Diffusional kurtosis imaging study in idiopathic normal pressure hydrocephalus patients, before and after shunt placement surgery analysis

Chanon Ngamsombat ¹, Zhe Zhang², Hua Gua², Theerapol Witthiwej³, Weerasak Muangpaisan⁴, Sith Sathornsumetee⁵, Suwit Charoensak⁶, Panida Charnchaowanish¹, and Orasa Chawalparit¹

¹Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand, ²Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, Beijing, China, People's Republic of, ³Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand, ⁴Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand, ⁵Departments of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand, ⁶Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand

Idiopathic normal pressure hydrocephalus(iNPH) is important reversible cause of dementia and gait abnormality in elderly patients. Diffusional kurtosis imaging(DKI) moreover explains the complexity of white matter abnormality with inclusion of non-Gaussian effects. We aim to identify difference of complexity of white matter alteration in iNPH patients before and after shunt placement surgery by using high resolution DKI. We report significant increase of mean diffusional kurtosis(Kmean), mean diffusivity(MD) and decrease of radial diffusional kurtosis(Krad) , fractional ansiotropy(FA) after shunt placement surgery. High resolution DKI can be used for monitoring and detection complexity of white matter alteration in iNPH patients.

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