Abstract #3498

The Investigation of Cerebral Microstructure Changes of Pediatric Patients With Type Ⅰ Gaucher Disease Using Diffusion Kurtosis Imaging

Huiying Kang¹, Ningning Zhang, Kaining Shi², Yanqiu Lv¹, Di Hu¹, and Yun Peng¹

¹Imaging center, Beijing Children’s Hospital, Capital Medical University, Beijing, China, People's Republic of, ²Imaging Systems Clinical Science, Philips Healthcare, Beijing, China, People's Republic of

Increasing clinical studies suggested that there are some type Ⅰ Gaucher disease (GDⅠ) patients suffering neurological symptom, which was originally defined as non-neuropathlogical involved. This study recruited 38 patients and 32 normal children to investigate morphological changes of brain in GDⅠ patients by using Diffusion Kurtosis Imaging. Our results showed significant decreased MD in bilateral olfactory gyrus, increased MD in right calcarine and substantia nigra and significant increased MK in right olfactory gyrus. Our study suggests a necessity of adjusting the opinion regarding the CNS-involvement of GDⅠ, and DKI analysis is a potential imaging marker in clinical studies of GDⅠ.

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