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Abstract #3574

Geometry of Basal Ganglia nuclei in QSM and Histology in Parkinson’s disease brains

Carsten Stueber1,2, Alexey Dimov1, Kofi Deh1, David Pitt2, and Yi Wang1

1Weill Cornell Medical College, New York, NY, United States, 2Yale School of Medicine, Yale University, New Haven, CT, United States

Quantitative susceptibility mapping (QSM) provides a quantitative MRI contrast, which reflects the local iron concentration. Thus, QSM allows to determine the geometries of iron-rich deep grey matter nuclei including substantia nigra (SN) and subthalamic nucleus (STN). These basal nuclei are of particular interest in Parkinson’s disease. However, the measured dimensions need to be validated in histology using post-mortem human brain tissue. In this work, we show the concordance of the geometries measured in QSM and histology using Perls’ iron stain, which opens the door to use QSM as a pre-surgical mapping for deep brain stimulation targeting the STN.

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