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Abstract #3575

Multi-parametric MRI Characterization of a Polymer Gel Dosimetry Phantom for Non-Invasive 3D Visualization of Radiation Deposition in Gamma Knife Therapy

Ivan E Dimitrov1,2 and Strahinja Stojadinovic3

1Philips Medical Systems, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States

Radiation therapy aims to maximize dose delivery to tumor areas while minimizing the exposure to healthy tissue. Quality control is required to ensure that the delivered dose closely matches the calculated dose. We performed a patient-specific quality assurance for cranial radiotherapy using MRI to visualize delivered radiation dose. We utilized an anthropomorphic 3D printed head phantom filled with polymer gel that was scanned before and after exposure to Gamma Knife irradiation. Irradiation changed the polymerization state of the gel and multi-parametric (T1, T2, MR Spectroscopy, CEST) quantitative dose-imaging maps were generated that may lead to optimized patient-specific dose delivery planning.

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