Multi-parametric MRI Characterization of a Polymer Gel Dosimetry Phantom for Non-Invasive 3D Visualization of Radiation Deposition in Gamma Knife Therapy
Ivan E Dimitrov1,2 and Strahinja Stojadinovic3
1Philips Medical Systems, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States
Radiation therapy aims to maximize dose delivery
to tumor areas while minimizing the exposure to healthy tissue. Quality control
is required to ensure that the delivered dose closely matches the calculated
dose. We performed a patient-specific
quality assurance for cranial radiotherapy using MRI to visualize delivered
radiation dose. We utilized an anthropomorphic 3D printed head phantom filled
with polymer gel that was scanned before and after exposure to Gamma Knife irradiation.
Irradiation changed the polymerization state of the gel and multi-parametric
(T1, T2, MR Spectroscopy, CEST) quantitative dose-imaging maps were generated that
may lead to optimized patient-specific dose delivery planning.
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