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Abstract #3576

TOLD MRI Validation of Reversal of Tumor Hypoxia in Glioblastoma with a Novel Oxygen Therapeutic

Heling Zhou1, David Wilson2, Jason Lickliter3, Jeremy Ruben4, Natarajan Raghunand5, Michael Sellenger6, Ralph P Mason7, and Evan Unger2,8

1UT Southwestern Medical Center, Dallas, TX, United States, 2NuvOx Pharma, Tucson, AZ, United States, 3Nucleus Networks, Melbourne, Australia, 4William Buckland Radiotherapy Centre, Melbourne, Australia, 5Moffitt Cancer Center, Tampa, FL, United States, 6Alfred Hospital, Prahran, Australia, 7Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 8Medical Imaging, The University of Arizona, Tucson, AZ, United States

Glioblastoma multiforme (GBM) is known to be a hypoxic tumor and hypoxia adversely affects response to radiation therapy. Dodecafluoropentane emulsion (DDFPe) can improve oxygenation. Tissue oxygen level dependent (TOLD) MRI is an oxygen sensitive imaging technique which is used in this study to assess the improvement of oxygenation after administration of DDFPe. Two different doses were tested and each showed decreased T1 indicating improved oxygenation.

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