Abstract #3581

A four-layer boundary element model for MRI-guided transcranial magnetic stimulation

Aapo Nummenmaa¹ and Matti Stenroos²

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland

MRI-guided targeting and dosing has the potential increase the consistency and efficacy of transcranial magnetic stimulation (TMS). We propose a boundary element method (BEM) approach for estimating the TMS-induced cortical electric fields (E-fields). The method can be applied based on standard T1/T2-weighted MRI data and can incorporate the cerebrospinal fluid (CSF) as a separate conductivity compartment. Our results show that the CSF layer may increase the estimated E-field amplitudes up to 25%. The effect of the CSF depends on the location and orientation of the TMS coil/target in a rather intricate manner, highlighting the importance of individualized, realistically shaped models.

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