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Abstract #3596

Real-Time Monitoring of Focused Ultrasound Induced Inertial Cavitation on Microbubbles by Using Gradient Echo MRI: in Vitro and in Vivo Experiments

Chen-Hua Wu1, Shih-Tsung Kang1, Chih-Kuang Yeh1, Wen-Shiang Chen2, and Hsu-Hsia Peng1

1Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu City, Taiwan, 2Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan

This study aims to real-time monitor inertial cavitation on microbubbles (MBs) while transmitting focused ultrasound (FUS) with various duty cycle and pulse repetitive frequency (PRF) by gradient echo MRI. For in vitro experiments, with increasing duty cycle, more significant signal intensity (SI) changes or prolonged SI drop duration were shown. For in vivo experiment, two SI drop peaks were observed, reflecting the two IC events. In conclusion, FLASH has been proved to be a useful technique for real-time monitoring of IC when transmitting FUS pulses to MBs for in vitro and in vivo experiments.

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