Multi-Contrast Late Enhancement Out-Performs Conventional Late Gadolinium Enhancement for Myocardial RFA Lesion Characterization
Philippa Krahn1,2, Haydar Celik3, Venkat Ramanan2, Jennifer Barry2, and Graham A Wright1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC, United States
In this work we evaluated the quality and accuracy of myocardial RFA lesion visualization using the MCLE sequence. To compare MCLE to the standard LGE, we imaged 29 acute lesions in 11 pigs. Lesion sizes measured from each set of images were highly correlated, yet MCLE consistently achieved higher CNR than LGE. Our relaxometry maps from MCLE suggested a dramatic variation in T1 after contrast injection, which will alter the optimal TI for LGE. Therefore, we demonstrated that MCLE, with the varied TIs in each acquisition, is a more robust sequence for visualizing even the most subtle lesions.
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