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Abstract #3607

Monitoring of Stable Cavitation of Microbubbles by Using MRI

Cheng-Tao Ho1, Chen-Hua Wu1, Shih-Tsung Kang1, Chih-Kuang Yeh1, Wen-Shiang Chen2, Hau-Li Liu3, and Hsu-Hsia Peng1

1Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu, Taiwan, 2Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, 3Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan

Gas-filled microbubbles (MBs) can be locally cavitated by spatially focused ultrasound (FUS) to trigger stable cavitation (SC) and inertial cavitation (IC) to induce blood–brain barrier (BBB) opening ; therefore, magnetic resonance imaging (MRI) may provide useful imaging information to real-time monitor the process of FUS cavitation on MBs. In this study, a HASTE (Half Fourier Acquisition Single Shot Turbo Spin Echo) sequence was used to observe the signal changes during SC for in vitro experiments. Experiments with different acoustic pressure, pulse repetitive frequency, and duty cycle were performed to clarify the SC effect on MR images.

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