Abstract #3607

Monitoring of Stable Cavitation of Microbubbles by Using MRI

Cheng-Tao Ho¹, Chen-Hua Wu¹, Shih-Tsung Kang¹, Chih-Kuang Yeh¹, Wen-Shiang Chen², Hau-Li Liu³, and Hsu-Hsia Peng¹

¹Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu, Taiwan, ²Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, ³Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan

Gas-filled microbubbles (MBs) can be locally cavitated by spatially focused ultrasound (FUS) to trigger stable cavitation (SC) and inertial cavitation (IC) to induce blood–brain barrier (BBB) opening ; therefore, magnetic resonance imaging (MRI) may provide useful imaging information to real-time monitor the process of FUS cavitation on MBs. In this study, a HASTE (Half Fourier Acquisition Single Shot Turbo Spin Echo) sequence was used to observe the signal changes during SC for in vitro experiments. Experiments with different acoustic pressure, pulse repetitive frequency, and duty cycle were performed to clarify the SC effect on MR images.

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