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Abstract #3668

Measuring Perfusion with a Hyperpolarised Ultra-Long T1 15N Glutamine Compound

Rolf F Schulte1, Enrico Chiavazza2,3, Axel Haase2, Silvio Aime3, Marion I Menzel1, Markus Schwaiger2, and Markus Durst1,2

1GE Global Research, Munich, Germany, 2Technische Universität München, Munich, Germany, 3Università di Torino, Turin, Italy

An experimental setup for 15N was established on a clinical 3T whole-body scanner, in order to measure perfusion with an ultra-long T1 15N compound. The substance α-trideuteromethyl[15N]glutamine was synthesised, polarised and injected into healthy rats to study the perfusion of the kidneys. With a T1 time in vivo of 146s, it was possible to acquire perfusion images for over 5 minutes.

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