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Abstract #3671

Hyperpolarized Carbon-13 Ketoisocaproate Reveals Dysfunction in Branched-Chain Amino Acid Metabolism in Liver Cancer

Philip Lee1, Xing Qi Teo1, and Way Cherng Chen1

1FUNCTIONAL METABOLISM GROUP, SINGAPORE BIOIMAGING CONSORTIUM, Singapore, Singapore

Complex reprogramming of cellular metabolism to support tumorigenesis & survival is a hallmark of cancer. Recently Ericksen et al observed that the suppression of branched-chain amino acids (BCAA) catabolic enzymes is a unique signature in human hepatocellular carcinomas (HCC), and the degree of downregulation correlates strongly with tumor grades and survival outcomes1. Specifically the metabolic activity of the branched-chain keto-acid dehydrogenase (BCKDH) complex was significantly reduced. We hypothesize that this modulation can be measured in vivo by tracking the metabolism of hyperpolarized carbon-13 ketoisocaproate.

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