Abstract #3671

Hyperpolarized Carbon-13 Ketoisocaproate Reveals Dysfunction in Branched-Chain Amino Acid Metabolism in Liver Cancer

Philip Lee¹, Xing Qi Teo¹, and Way Cherng Chen¹

¹FUNCTIONAL METABOLISM GROUP, SINGAPORE BIOIMAGING CONSORTIUM, Singapore, Singapore

Complex reprogramming of cellular metabolism to support tumorigenesis & survival is a hallmark of cancer. Recently Ericksen et al observed that the suppression of branched-chain amino acids (BCAA) catabolic enzymes is a unique signature in human hepatocellular carcinomas (HCC), and the degree of downregulation correlates strongly with tumor grades and survival outcomes1. Specifically the metabolic activity of the branched-chain keto-acid dehydrogenase (BCKDH) complex was significantly reduced. We hypothesize that this modulation can be measured in vivo by tracking the metabolism of hyperpolarized carbon-13 ketoisocaproate.

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