Abstract #3672

Noninvasive in vivo assessment of cytosolic redox-state in rat liver using hyperpolarized [1-13C]alanine

Jae Mo Park¹, Ralph E Hurd², Shie-Chau Liu¹, and Daniel M Spielman¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA, United States

Intracellular [lactate]:[pyruvate] is an important biomarker of cytosolic redox-state, directly reflecting free cytosolic [NADH]:[NAD⁺]. Hyperpolarized [1-¹³C]alanine, which can be also transported across the plasma membrane, is useful to measure relative concentrations of intracellular pyruvate and lactate. In this work, we propose a simple method to assess in vivo cytosolic redox-state using hyperpolarized [1-¹³C]alanine, and demonstrate the ethanol-induced redox change in rat liver.

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