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Abstract #3673

­In-vivo Assessment of Lung Injury Using Hyperpolarized Carbon-13 MRI in a Two-hit Model of Acid Aspiration and VILI

Mehrdad Pourfathi1,2, Yi Xin1, Stephen J Kadlecek1, Maurizio Cereda3, Harrilla Profka1, Sarmad M Siddiqui1,4, Hooman Hamedani1,4, and Rahim R Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, United States, 3Anesthesiology and Critical Care, University of Pennsylvania, Perlman School of Medicine, Philadelphia, PA, United States, 4Bioengineering, University of Pennsylvania, Philadelphia, PA, United States

Ventilator induced lung injury (VILI) results from mechanical trauma and secondary inflammatory responses. Previous imaging studies focused on the effects of ventilator settings on structural or functional changes; however, no MRI studies have been conducted to elucidate the metabolic changes during VILI. In this study, the potential of HP [1-13C]-pyruvate and its conversion to [1-13C]-lactate as a marker for the lung inflammation was investigated in a two-hit model of acid aspiration and VILI.

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