Abstract #3674

Zymonic acid - a novel 13C enriched biosensor for in vivo pH-imaging

Christian Hundshammer^1,2, Stephan Düwel¹, Malte Gersch³, Benedikt Feuerecker¹, Axel Haase⁴, Markus Schwaiger¹, Steffen J. Glaser³, and Franz Schilling¹

¹Department of Nuclear Medicine, Klinikum rechts der Isar, München, Germany, ²Department of Chemistry, Technische Universität München, München, Germany, ³Department of Chemistry, Technische Universität München, Garching, Germany, ⁴Department of Medical Engineering, Technische Universität München, Garching, Germany

[1,5-¹³C₂] Zymonic acid is derived from carbon 13 labelled pyruvic acid and can be easily deuterium enriched for spin lattice relaxation time prolongation. The molecule exhibits pH dependent NMR shifts and can be used for pH in vivo mapping. Phantom measurements on human blood on a 7T preclinical MRI system indicate that [1,5-¹³C₂] ZA is a suitable pH sensor for pre-clinical and potentially also for clinical applications.

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