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Abstract #3674

Zymonic acid - a novel 13C enriched biosensor for in vivo pH-imaging

Christian Hundshammer1,2, Stephan Düwel1, Malte Gersch3, Benedikt Feuerecker1, Axel Haase4, Markus Schwaiger1, Steffen J. Glaser3, and Franz Schilling1

1Department of Nuclear Medicine, Klinikum rechts der Isar, München, Germany, 2Department of Chemistry, Technische Universität München, München, Germany, 3Department of Chemistry, Technische Universität München, Garching, Germany, 4Department of Medical Engineering, Technische Universität München, Garching, Germany

[1,5-13C2] Zymonic acid is derived from carbon 13 labelled pyruvic acid and can be easily deuterium enriched for spin lattice relaxation time prolongation. The molecule exhibits pH dependent NMR shifts and can be used for pH in vivo mapping. Phantom measurements on human blood on a 7T preclinical MRI system indicate that [1,5-13C2] ZA is a suitable pH sensor for pre-clinical and potentially also for clinical applications.

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