Abstract #3675

pH Dependent Kinetics of the Decarboxylation of Pyruvate for pH Mapping Experiments

Nicholas Drachman¹, Stephen J. Kadlecek¹, Yi Xin¹, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States

We have shown that the kinetic rate of the production of bicarbonate from pyruvate is heavily pH dependent. An increase in the rate by a factor of ~10 can be achieved by maintaining the pH of the reaction always above 10.3, the pKa of bicarbonate. This discovery will allow researchers to quickly produce hyperpolarized bicarbonate to be used for in vivo pH mapping experiments.

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