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Abstract #3676

In Vivo Hyperpolarized 13C Diffusion Weighted MRI Measures Lactate Efflux and Changes in MCT4 Expression in Prostate Cancer

Jeremy W Gordon1, Hecong Qin1, Renuka Sriram1, Robert Bok1, Peder EZ Larson1, Daniel B Vigneron1, and John Kurhanewicz1

1Radiology & Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States

Dissolution DNP provides a 10,000-fold signal enhancement to carbon-13 nuclei and enables real-time metabolic imaging. In addition to the Warburg Effect, many malignant cancers overexpress MCT4, the monocarboxylate transporter responsible for lactate efflux and extracellular acidification. Because of microenvironmental differences, diffusion weighted imaging (DWI) with hyperpolarized substrates may provide unique information on lactate efflux and MCT4 expression. Here we show that DWI with hyperpolarized substrates is sensitive to changes in MCT4 expression, as lactate ADC is increased by >40% in late-stage TRAMP tumors. This technique may potentially provide a novel way to assess metabolite compartmentalization and transporter expression in malignant disease.

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