Abstract #3677

Early diabetic kidney maintains the cortico-medullary urea and sodium gradient

Haiyun Qi¹, Thomas Stokholm Nørlinger¹, Per Mose Nielsen¹, Lotte Bonde Bertelsen¹, Yafang Xu¹, Fredrik Palm², Hans Stødkilde-Jørgensen¹, and Christoffer Laustsen¹

¹MR Research Centre, Aarhus University, Aarhus N, Denmark, ²Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

To investigate the essential intrarenal electrolyte gradients in early diabetic kidneys, hyperpolarized 13C urea was applied to measure urea and sodium gradients. No differences in either intrarenal urea or sodium gradients were observed in early diabetes compared to healthy controls. These results indicate that the early metabolic and hypertrophic changes occurring in the diabetic kidney prelude the later functional alterations in diabetic kidney function, thus driving the increased metabolic demand commonly occurring in the diabetic kidney.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.