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Abstract #3677

Early diabetic kidney maintains the cortico-medullary urea and sodium gradient

Haiyun Qi1, Thomas Stokholm Nørlinger1, Per Mose Nielsen1, Lotte Bonde Bertelsen1, Yafang Xu1, Fredrik Palm2, Hans Stødkilde-Jørgensen1, and Christoffer Laustsen1

1MR Research Centre, Aarhus University, Aarhus N, Denmark, 2Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

To investigate the essential intrarenal electrolyte gradients in early diabetic kidneys, hyperpolarized 13C urea was applied to measure urea and sodium gradients. No differences in either intrarenal urea or sodium gradients were observed in early diabetes compared to healthy controls. These results indicate that the early metabolic and hypertrophic changes occurring in the diabetic kidney prelude the later functional alterations in diabetic kidney function, thus driving the increased metabolic demand commonly occurring in the diabetic kidney.

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