Abstract #3679

Sampling Hyperpolarized Substrates using a 1 Tesla Permanent Magnet.

Sui-Seng Tee¹, Valentina Digialleonardo¹, Hannah Nikki Aldeborgh¹, Julio Alvarez¹, Alex Poot¹, and Kayvan Rahimi Keshari¹

¹Radiology, MSKCC, New York, NY, United States

Hyperpolarized MRI quantifies metabolic fluxes non-invasively. One limitation is the rapid loss of polarized signal, decaying according to its longitudinal relaxation (T₁) time. We propose the use of a permanent, 1 Tesla spectrometer to lengthen T₁s. We show longer T₁ values across different functional groups. Scalar couplings were also visible and these advantages were translatable to biologically-relevant settings using perfused bioreactors. As more clinical trials are performed, it is essential to understand the behavior of HP molecules at field strengths similar to hospital magnets. Sampling HP substrates using permanent magnets is simple and cost-effective and will directly benefit clinical imaging.

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