Abstract #3684

LED induced 19F-MR-signal enhancement at 7T

Markus Plaumann¹, Thomas Trantzschel¹, Joachim Bargon², Ute Bommerich¹, and Johannes Bernarding¹

¹Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, ²Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany

¹⁹F containing substrates serve as attractive reporter molecules for NMR and MRI studies. Applications for in vivo studies are limited by low spin densities due to restricted concentrations. Using hyperpolarization techniques, such as Chemically Induced Dynamic nuclear Polarization (CIDNP), this constrained can be overcome. So far, ¹⁹F hyperpolarization generated in D₂O, which is a prerequisite for an in vivo application, could only be documented using laser photo-CIDNP. In this study the successful hyperpolarization of a ¹⁹F nucleus in in 3-fluoro-DL-tyrosine in its free and a complexed form using D₂O as a solvent is presented using a simple LED photo-CIDNP device.

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