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Abstract #3684

LED induced 19F-MR-signal enhancement at 7T

Markus Plaumann1, Thomas Trantzschel1, Joachim Bargon2, Ute Bommerich1, and Johannes Bernarding1

1Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, 2Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany

19F containing substrates serve as attractive reporter molecules for NMR and MRI studies. Applications for in vivo studies are limited by low spin densities due to restricted concentrations. Using hyperpolarization techniques, such as Chemically Induced Dynamic nuclear Polarization (CIDNP), this constrained can be overcome. So far, 19F hyperpolarization generated in D2O, which is a prerequisite for an in vivo application, could only be documented using laser photo-CIDNP. In this study the successful hyperpolarization of a 19F nucleus in in 3-fluoro-DL-tyrosine in its free and a complexed form using D2O as a solvent is presented using a simple LED photo-CIDNP device.

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