Abstract #3686

Hyperpolarized 1-13C Pyruvate Imaging of Porcine Cardiac Metabolism shift by GIK Intervention

Esben Søvsø Szocska Hansen^1,2, Rasmus Stilling Tougaard^1,3, Emmeli Mikkelsen¹, Thomas Stokholm Nørlinger¹, Lotte Bonde Bertelsen¹, Steffen Ringgaard¹, Hans Stødkilde-Jørgensen¹, and Christoffer Laustsen¹

¹MR Research Centre, Aarhus University, Aarhus N, Denmark, ²Danish Diabetes Academy, Odense, Denmark, ³Cardiology, Aarhus University Hospital, Aarhus N, Denmark

Cardiac metabolism has gained considerable attention worldwide lately, both as a diagnostic and prognostication tool, as well as a novel target for treatment. As human trials involving hyperpolarized MR in the heart are imminent, we employed a clinically relevant, large animal model, and sought to evaluate the general feasibility to detect an imposed shift in metabolic substrate utilization during metabolic modulation with glucose, insulin and potassium (GIK) infusion. This study demonstrates that hyperpolarized ¹³C-pyruvate, in a large animal, is a feasible method for cardiac studies, and, in combination with GIK intervention; that it is able to detect imposed metabolic shifts.

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