Abstract #3687

Para-Hydrogen Induced Polarization: Advances in Amino Acid Polarization and Hyperpolarization in Heterogeneous Phase

Stefan Glöggler¹, Alex Grunfeld², Jeff McCormick², Yavuz Ertas², Phillipp Schleker³, Shawn Wagner⁴, and Louis-Serge Bouchard²

¹University of Southampton, Southampton, United Kingdom, ²University of California Los Angeles, Los Angeles, CA, United States, ³RWTH Aachen University, Aachen, Germany, ⁴Cedars Sinai Medical Center, Los Angeles, CA, United States

We present new amino acid derivatives that can be hyperpolarized with the Para-Hydrogen Induced Polarization method (PHIP). Furthermore, we report on the highest achieved polarization of amino acid derivatives in biocompatible medium (water) to date with relevance for in vivo applications. Moreover, the first heterogeneous catalyst for PHIP in water will be presented that leads to significant levels of polarization. This poses the possiblity of a quick filtration step to yield clean PHIP-polarized contrast agents for future in vivo studies.

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