Para-Hydrogen Induced Polarization: Advances in Amino Acid Polarization and Hyperpolarization
in Heterogeneous Phase
Stefan Glöggler1, Alex Grunfeld2, Jeff McCormick2, Yavuz Ertas2, Phillipp Schleker3, Shawn Wagner4, and Louis-Serge Bouchard2
1University of Southampton, Southampton, United Kingdom, 2University of California Los Angeles, Los Angeles, CA, United States, 3RWTH Aachen University, Aachen, Germany, 4Cedars Sinai Medical Center, Los Angeles, CA, United States
We present new amino acid derivatives that can be hyperpolarized with the Para-Hydrogen Induced Polarization method (PHIP). Furthermore, we report on the highest achieved polarization of amino acid derivatives in biocompatible medium (water) to date with relevance for in vivo applications. Moreover, the first heterogeneous catalyst for PHIP in water will be presented that leads to significant levels of polarization. This poses the possiblity of a quick filtration step to yield clean PHIP-polarized contrast agents for future in vivo studies.
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