Abstract #3688

First hyperpolarization of quaternary pyridinium salts using PHIP

Frederike Euchner¹, Rainer Ringleb¹, Joachim Bargon², Ute Bommerich¹, Johannes Bernarding¹, and Markus Plaumann¹

¹Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, ²Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany

Quaternary ammonium substrates are of huge interest in the pharmaceutical field. Here, the hyperpolarization of new fluorinated pyridinium ions was examined. The effect of the positive charged nitrogen relating to the polarization transfer inside the molecule was proven and compared with the ¹H, ¹³C and ¹⁹F hyperpolarization examinations of 2-(3-fluoro-phenyl)-3-buten-2-ol. The observed effect can be used for localization of polarization and for the synthesis of extened MR signal enhancements.

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