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Abstract #3688

First hyperpolarization of quaternary pyridinium salts using PHIP

Frederike Euchner1, Rainer Ringleb1, Joachim Bargon2, Ute Bommerich1, Johannes Bernarding1, and Markus Plaumann1

1Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, 2Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany

Quaternary ammonium substrates are of huge interest in the pharmaceutical field. Here, the hyperpolarization of new fluorinated pyridinium ions was examined. The effect of the positive charged nitrogen relating to the polarization transfer inside the molecule was proven and compared with the 1H, 13C and 19F hyperpolarization examinations of 2-(3-fluoro-phenyl)-3-buten-2-ol. The observed effect can be used for localization of polarization and for the synthesis of extened MR signal enhancements.

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