Abstract #3689

Hyperpolarized [1-13C]pyruvate and [1-13C]lactate observed using a single shot 3D pulse sequence in vivo

Jiazheng Wang¹, Alan Wright¹, De-en Hu¹, Richard Hesketh¹, and Kevin M. Brindle^1,2

¹Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ²Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

We have developed a single-shot 3D sequence for hyperpolarized ¹³C MRI, with a spatial-spectral (SpSp) pulse for excitation and a stack-of-spirals acquired in interleaved fashion during two spin echoes. The sequence achieved a resolution of 1.25x1.25x2.5 mm³ in vivo on a 7T animal system, where hyperpolarized [1-¹³C]pyruvate and [1-¹³C]lactate were imaged alternately at a frame rate of 2 s per metabolite. Variations are allowed in the design of the acquisition train to balance the in-plane and through-plane resolutions. This sequence allows higher temporal resolution and less RF depletion of the polarization than pulse sequences described previously.

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