Abstract #3692

Imaging in vitro and in vivo pH with ioversol by CEST MRI

Miaomiao Chen¹, Xiaolei Zhang¹, Yanzi Chen¹, Zhiwei Shen¹, Wei Hu¹, Xilun Ma¹, and Renhua Wu¹

¹Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou, China, People's Republic of

We have developed a CEST MRI method that can measure pH using ioversol, a contrast agent that is clinically approved for X-ray imaging and has been repurposed for CEST MRI studies. Using ioversol as a CEST agent, we have measured pH over a range of 6.0 - 7.8 pH units by a novel ratiometric pH MRI method, in a concentration-independent manner. We also have used this agent and CEST MRI method to measure the extracellular pH (pHe) within the liver of healthy SD rats.

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