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Abstract #3692

Imaging in vitro and in vivo pH with ioversol by CEST MRI

Miaomiao Chen1, Xiaolei Zhang1, Yanzi Chen1, Zhiwei Shen1, Wei Hu1, Xilun Ma1, and Renhua Wu1

1Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou, China, People's Republic of

We have developed a CEST MRI method that can measure pH using ioversol, a contrast agent that is clinically approved for X-ray imaging and has been repurposed for CEST MRI studies. Using ioversol as a CEST agent, we have measured pH over a range of 6.0 - 7.8 pH units by a novel ratiometric pH MRI method, in a concentration-independent manner. We also have used this agent and CEST MRI method to measure the extracellular pH (pHe) within the liver of healthy SD rats.

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