Abstract #3693

15N Heteronuclear Chemical Exchange Saturation Transfer MRI Imaging

Haifeng Zeng^1,2, Jiadi Xu^1,2, Nirbhay N Yadav^1,2, Michael T McMahon^1,2, Bradley Harden³, Dominique Frueh³, and Peter C.M van Zijl^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, United States

A two-step heteronuclear enhancement approach to magnify ¹⁵N MRI signal through indirect detection of water is described. Chemical Exchange Saturation Transfer (CEST) works by continuously perturbation of the spin magnetization of the exchangeable spins, and then through chemical exchange to accumulate this perturbation on water proton for signal magnification. This perturbation is mainly limited to saturation or excitation pulse on the exchangeable protons. In this work, the signal of ¹⁵N is detected indirectly through the water signal by first inverting selectively protons scalar-coupled to ¹⁵N in the urea molecule, followed by chemical exchange of the amide proton to bulk water.

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