Abstract #3701

MRI-Guided Thermosensitive Liposomal Drug Delivery for Cancer Therapy

Po-Wah So¹, Maral Amrahli², Michael Wright², Miguel Centelles², Wladyslaw Gedroyc³, Andrew Miller², and Maya Thanou²

¹Neuroimaging, King's College London, London, United Kingdom, ²Institute of Pharmaceutical Sciences, King's College London, London, United Kingdom, ³Experimental Medicine, Imperial College London, london, United Kingdom

We have designed and synthesised a novel liposome formulation, capable of releasing encapsulated drug on targeting/heating by focussed ultrasound (FUS) for cancer therapy and being visualised by MRI due to the incorporation of gadolinium chelates. We show the novel liposomes are targeted to tumours by FUS and MRI-visible in vivo and thus, suitable for theranostic applications in cancer.

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