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Abstract #3702

Towards Early Detection of Pancreatic Cancers by Active Feedback MR Molecular Imaging

Chaohsiung Hsu1, Zhao Li1, Ryan Quiroz1, Raymond Ngo1, and Yung-Ya Lin1

1Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, United States

Early detection of pancreatic cancers using enhanced MRI techniques increases not only the treatment options available, but also the patients’ survival rate. This can be achieved with antibody-conjugated superparamagnetic iron oxide (SPIO) nanoparticles capable of binding to early stage pancreatic cancer cells to improve imaging specificity and innovation methods that can sensitively detect SPIO to improve imaging sensitivity. The enhanced contrast from SPIO can then be used to visually assess the distribution and magnitude of SPIO-targeted tumor cells. In vivo subcutaneous and orthotopic xenografts mouse models validated the superior contrast/sensitivity and robustness of this approach towards early pancreatic cancers detection.

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