Abstract #3703

Real Time Detection of Pancreatic Cancer-induced Cachexia using a Fluorescent Myoblast Reporter and 1H MRS Metabolic Analysis

Paul Thomas Winnard Jr¹, Santosh Bharti¹, Marie-France Penet¹, Radharani Marik¹, Yelena Mironchik¹, Flonne Wildes¹, Anirban Maitra², and Zaver M Bhujwalla¹

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²MD Anderson Cancer Center, Houston, TX, United States

Therapeutic options for cancer-induced cachexia are limited and therefore, efforts to identify signs of precachexia in cancer patients are necessary for early intervention. Here, we generated a myoblast cell line expressing a dual dTomato:GFP construct that was grafted onto the muscle of mice bearing human pancreatic cancer xenografts to provide noninvasive live imaging of events associated with cancer-induced cachexia (i.e., weight loss). ¹H MRS revealed that weight loss in cachectic animals was associated with a depletion of plasma lipid, cholesterol, and valine, and decreased skeletal muscle alanine levels, which may provide informative biomarkers of cachexia.

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