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Abstract #3708

Arterial spin labeling can detect discreet changes of renal perfusion after oral application of the pain medication diclofenac in healthy subjects

Susanne Tewes1, Marcel Gutberlet1, Van Dai Vo Chieu1, Dagmar Hartung1, Sebastian Rauhut2, Matti Peperhove1, Frank Wacker1, Faikah Gueler2, and Katja Hueper1

1Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Clinic for Nephrology, Hannover Medical School, Hannover, Germany

Diclofenac is a nonsteroidal anti-inflammatory drug that is frequently prescribed to reduce inflammation and pain. It reduces the prostaglandin-synthesis and may consequently have an effect on renal perfusion. We investigated whether arterial spin labeling can detect reduction of renal perfusion after oral and topical application of diclofenac compared to baseline measurements. Ten healthy subjects underwent functional MRI of the kidney. After oral application of diclofenac renal perfusion was reduced compared to baseline measurements (321±13 vs. 345±16 ml/(min*100g), p<0.01). No significant changes were found after topical application. In conclusion, ASL can detect discreet changes of renal perfusion that occur after application of diclofenac.

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