Abstract #3707

Comparison Study between T2*, Quantitative Susceptibility Mapping (QSM), and Histology for Postmortem Human Substantia Nigra

Jae-Hyeok Lee¹, Sun-Yong Baek², YoungKyu Song³, Sujeong Lim³, Hansol Lee³, Minh Phuong Nguyen⁴, Eun-Joo Kim⁵, Gi Yeong Huh⁶, Se Young Chun⁴, and HyungJoon Cho³

¹Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of, ²Department of Anatomy, Pusan National University School of Medicine, Yangsan, Korea, Republic of, ³Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, ⁴Department of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, ⁵Department of Neurology, Pusan National University Hospital, Busan, Korea, Republic of, ⁶Department of Forensic Medicine, Pusan National University School of Medicine, Yangsan, Korea, Republic of

Selective iron deposition in the substantia nigra (SN) along with the gradual loss of neuromelanin cell (NMC) is known to be associated with neurodegenerative diseases, such as Parkinson's disease. Postmortem 40-year-old male and 70-year-old female SN tissues were scanned at various spatial resolutions with 7T MRI. The association of T2* and QSM-derived susceptibility values with quantitative NMC and iron from Perl's Prussian blue staining were investigated with precise co-registration of MRI and histology. We identified that T2* and susceptibility values for NMC and iron regions, which were segmented from histology were significantly different from corresponding values of background tissue area.

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