Meeting Banner
Abstract #3707

Comparison Study between T2*, Quantitative Susceptibility Mapping (QSM), and Histology for Postmortem Human Substantia Nigra

Jae-Hyeok Lee1, Sun-Yong Baek2, YoungKyu Song3, Sujeong Lim3, Hansol Lee3, Minh Phuong Nguyen4, Eun-Joo Kim5, Gi Yeong Huh6, Se Young Chun4, and HyungJoon Cho3

1Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of, 2Department of Anatomy, Pusan National University School of Medicine, Yangsan, Korea, Republic of, 3Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, 4Department of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, 5Department of Neurology, Pusan National University Hospital, Busan, Korea, Republic of, 6Department of Forensic Medicine, Pusan National University School of Medicine, Yangsan, Korea, Republic of

Selective iron deposition in the substantia nigra (SN) along with the gradual loss of neuromelanin cell (NMC) is known to be associated with neurodegenerative diseases, such as Parkinson's disease. Postmortem 40-year-old male and 70-year-old female SN tissues were scanned at various spatial resolutions with 7T MRI. The association of T2* and QSM-derived susceptibility values with quantitative NMC and iron from Perl's Prussian blue staining were investigated with precise co-registration of MRI and histology. We identified that T2* and susceptibility values for NMC and iron regions, which were segmented from histology were significantly different from corresponding values of background tissue area.

This abstract and the presentation materials are available to members only; a login is required.

Join Here