Iron accumulation in rat brain with frequent USPIO administration
Kofi Deh1, Andrew Gorman2, Caspar Schwiedrzik3, Pascal Spincemaille1, Martin Prince1, and Yi Wang1
1Weill Cornell Medical College, New York, NY, United States, 2Tri-Institutional Training Program in Laboratory Animal Medicine and Science, New York, NY, United States, 3The Rockefeller University, New York, NY, United States
An observation of signal loss on
functional MRI images of primates following repeated administration of ultra-small
super-paramagnetic iron oxide (USPIO) particles, led us to test a hypothesis of
iron accumulation in the brain by performing weekly quantitative susceptibility
mapping (QSM) of rats receiving daily USPIO injections for 9 weeks. We observed rapid increase in the
susceptibility values in brain ventricles and choroid plexus confirmed by
serum iron measurements and histology. In light of a similar report in the
literature, we recommend monitoring patients receiving iron therapy with a
susceptibility imaging technique such as QSM.
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