Abstract #3706

Iron accumulation in rat brain with frequent USPIO administration

Kofi Deh¹, Andrew Gorman², Caspar Schwiedrzik³, Pascal Spincemaille¹, Martin Prince¹, and Yi Wang¹

¹Weill Cornell Medical College, New York, NY, United States, ²Tri-Institutional Training Program in Laboratory Animal Medicine and Science, New York, NY, United States, ³The Rockefeller University, New York, NY, United States

An observation of signal loss on functional MRI images of primates following repeated administration of ultra-small super-paramagnetic iron oxide (USPIO) particles, led us to test a hypothesis of iron accumulation in the brain by performing weekly quantitative susceptibility mapping (QSM) of rats receiving daily USPIO injections for 9 weeks. We observed rapid increase in the susceptibility values in brain ventricles and choroid plexus confirmed by serum iron measurements and histology. In light of a similar report in the literature, we recommend monitoring patients receiving iron therapy with a susceptibility imaging technique such as QSM.

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