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Abstract #3706

Iron accumulation in rat brain with frequent USPIO administration

Kofi Deh1, Andrew Gorman2, Caspar Schwiedrzik3, Pascal Spincemaille1, Martin Prince1, and Yi Wang1

1Weill Cornell Medical College, New York, NY, United States, 2Tri-Institutional Training Program in Laboratory Animal Medicine and Science, New York, NY, United States, 3The Rockefeller University, New York, NY, United States

An observation of signal loss on functional MRI images of primates following repeated administration of ultra-small super-paramagnetic iron oxide (USPIO) particles, led us to test a hypothesis of iron accumulation in the brain by performing weekly quantitative susceptibility mapping (QSM) of rats receiving daily USPIO injections for 9 weeks. We observed rapid increase in the susceptibility values in brain ventricles and choroid plexus confirmed by serum iron measurements and histology. In light of a similar report in the literature, we recommend monitoring patients receiving iron therapy with a susceptibility imaging technique such as QSM.

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