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Abstract #3712

­­APT MRI of Intracranial Mass Lesions at 3T and Comparison with DCE Perfusion Parameters

Ayan Debnath1, Prativa Sahoo2, Pradeep Gupta3, Rakesh Gupta3, and Anup Singh1

1Centre for Bio-Medical Engineering, Indian Institute of Technolgy Delhi, Delhi, India, 2Philips India Limited, New Delhi, India, 3Radiology, Fortis Memorial Research Institute, New Delhi, India

In the current study, Amide Proton Transfer (APT) and T1-weighted DCE perfusion MRI was performed on patients with intra-cranial mass lesions(low and high grade tumors, CNS tuberculoma, CNS lymphoma) at 3T MRI. APT maps provided a significant difference between lesion and its contra-lateral side. From the preliminary study it was observed that APT contrast was low in infection lesion followed by tumor and lymphoma. APT values showed a significant (P<0.01) difference between low and high grade tumors. A weak Inter-class correlation was observed between APT and perfusion parameters (like cbf, cbv, Ktr, Kep, ve). Therefore, APT mapping might improve diagnostic value either alone or in combination with other MRI parameters.

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