Ayan Debnath1, Prativa Sahoo2, Pradeep Gupta3, Rakesh Gupta3, and Anup Singh1
1Centre for Bio-Medical Engineering, Indian Institute of Technolgy Delhi, Delhi, India, 2Philips India Limited, New Delhi, India, 3Radiology, Fortis Memorial Research Institute, New Delhi, India
In the current study, Amide Proton Transfer (APT) and T1-weighted DCE
perfusion MRI was performed on patients
with intra-cranial mass lesions(low and high grade tumors, CNS tuberculoma, CNS
lymphoma) at 3T MRI. APT maps provided a significant difference between lesion
and its contra-lateral side. From the preliminary study it was observed that
APT contrast was low in infection lesion followed by tumor and lymphoma. APT values showed a
significant (P<0.01) difference between low and high grade tumors. A
weak Inter-class correlation was observed between APT and perfusion parameters (like
cbf, cbv, Ktr, Kep, ve). Therefore, APT mapping might improve diagnostic value
either alone or in combination with other MRI parameters.
