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Abstract #3735

The impact of through-slice acceleration on the optimum TE in BOLD-based fMRI: a simulation study

Wietske van der Zwaag1, David G. Norris2, and José P. Marques2

1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 2Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands

In this simulation study we evaluate the TE that offers the optimum BOLD contrast per unit time for a given field strength (taking into account the field-specific T1, T2* and ΔT2* values) as a function of the number of slice excitations to acquire the volume (minimum TR achievable), using the Ernst angle for excitation. Generally, optimum BOLD sensitivity is found at TEs closer to T2* when shorter TRs (higher multiband acceleration factors) are employed. At longer TRs efficiency constraints tend to make the optimum TE shorter with this effect being more pronounced at lower static fields.

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