Abstract #3735

The impact of through-slice acceleration on the optimum TE in BOLD-based fMRI: a simulation study

Wietske van der Zwaag¹, David G. Norris², and José P. Marques²

¹Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, ²Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands

In this simulation study we evaluate the TE that offers the optimum BOLD contrast per unit time for a given field strength (taking into account the field-specific T₁, T₂^* and ΔT₂^* values) as a function of the number of slice excitations to acquire the volume (minimum TR achievable), using the Ernst angle for excitation. Generally, optimum BOLD sensitivity is found at TEs closer to T₂^* when shorter TRs (higher multiband acceleration factors) are employed. At longer TRs efficiency constraints tend to make the optimum TE shorter with this effect being more pronounced at lower static fields.

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