Abstract #3736

Evaluation of PCASL Imaging and T2* Mapping for the Assessment of Cerebrovascular Reactivity in the Hippocampus

Xiufeng Li¹, Nicholas Evanoff², Lynn E. Eberly ³, Anne M. Murray⁴, Gregory J. Metzger¹, and Donald R. Dengel²

¹Center for Magnetic Resonance Research, School of Medicine, University of Minnesota, Minneapolis, MN, United States, ²Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN, United States, ³Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States, ⁴Berman Center for Clinical Research, Hennepin County Medical Center, Minneapolis, MN, United States

The hippocampus is significantly affected in cognitive impairment, including Alzheimer’s disease. Cerebrovascular endothelial dysfunction (CeV-ED) plays an essential role in the initiation and progression of cerebrovascular disease (CeV-D) and cognitive decline. CeV-ED can be assessed with the evaluation of cerebrovascular reactivity (CeV-R) by performing MRI studies with a respiratory challenge, such as the manipulation of end-tidal partial pressure of CO₂ (PetCO₂) and O2 (PetO₂). In the presented studies, ASL imaging and T₂* mapping were evaluated for the assessment of the CeV-R in the hippocampus to determine the benefits and disadvantages of each imaging method and to facilitate the imaging method selection for future application studies.

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