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Abstract #3736

Evaluation of PCASL Imaging and T2* Mapping for the Assessment of Cerebrovascular Reactivity in the Hippocampus

Xiufeng Li1, Nicholas Evanoff2, Lynn E. Eberly 3, Anne M. Murray4, Gregory J. Metzger1, and Donald R. Dengel2

1Center for Magnetic Resonance Research, School of Medicine, University of Minnesota, Minneapolis, MN, United States, 2Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN, United States, 3Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States, 4Berman Center for Clinical Research, Hennepin County Medical Center, Minneapolis, MN, United States

The hippocampus is significantly affected in cognitive impairment, including Alzheimer’s disease. Cerebrovascular endothelial dysfunction (CeV-ED) plays an essential role in the initiation and progression of cerebrovascular disease (CeV-D) and cognitive decline. CeV-ED can be assessed with the evaluation of cerebrovascular reactivity (CeV-R) by performing MRI studies with a respiratory challenge, such as the manipulation of end-tidal partial pressure of CO2 (PetCO2) and O2 (PetO2). In the presented studies, ASL imaging and T2* mapping were evaluated for the assessment of the CeV-R in the hippocampus to determine the benefits and disadvantages of each imaging method and to facilitate the imaging method selection for future application studies.

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