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Abstract #3750

Chronic RF-coil and electrode implantation approach for long-term EEG-fMRI studies in rodents

Tiina Pirttimäki1, Artem Shatillo1, Mikko Kettunen1, Jaakko Paasonen1, Raimo Salo1, Alejandra Sierra Lopez 1, Kimmo Jokivarsi1, Ville Leinonen2, Simon Quittek3, Asla Pitkänen1, and Olli Gröhn1

1Neurobiology, A.I.Virtanen Institute for Molecular Medicine, University of Eastern Finland, Kuopio, Finland, 2Institute of Clinical Medicine - Neurosurgery, University of Eastern Finland and Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland, 3RAPID Biomedical GmbH Technologiepark Wuerzburg-Rimpar, Rimpar, Germany

Simultaneous EEG-fMRI is routinely used in clinical settings as it provides better temporal and spatial information for example when locating seizure onset zones. In pre-clinical research with small rodents, obtaining simultaneous EEG-fMRI in longitudinal studies has been challenged by a number problems including issues related to magnetic susceptibility artifacts. Here, we demonstrate a modified method for permanent MRI coil and EEG electrode implantation that is suitable for long-term chronic follow-up studies on epileptogenesis with improved data consistency across imaging and video-EEG monitoring sessions.

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