Abstract #3751

Longitudinal resting-state fMRI and 1H-MRS characterization in the mouse brain during development of a chronic pain state

David Bühlmann^1,2, Joanes Grandjean¹, Giovanna Diletta Ielacqua¹, Jael Xandry³, and Markus Rudin^1,3

¹Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, ²Neuroscience Center Zurich, Zurich, Switzerland, ³Institute of Pharmacology & Toxicology, University of Zurich, Zurich, Switzerland

We performed longitudinal resting-state fMRI and single voxel ¹H-MRS in a mouse model of chronic pain derived from bone cancer. Linear mixed model analysis of independent components revealed significant functional changes mostly in limbic but also cortical networks. These findings were reproducible across strains and mirror findings from clinical studies on chronic back pain patients. ¹H-MRS in the affected ventral hippocampus yielded significant decreases in glutamate, myo-inositol and glycerylophosphorylcholine concentrations in tumor-animals as well as increased glutamine levels. Given the translatability, these readouts could potentially be used to evaluate novel treatments specifically for chronic pain.

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