Meeting Banner
Abstract #3751

Longitudinal resting-state fMRI and 1H-MRS characterization in the mouse brain during development of a chronic pain state

David B├╝hlmann1,2, Joanes Grandjean1, Giovanna Diletta Ielacqua1, Jael Xandry3, and Markus Rudin1,3

1Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, 2Neuroscience Center Zurich, Zurich, Switzerland, 3Institute of Pharmacology & Toxicology, University of Zurich, Zurich, Switzerland

We performed longitudinal resting-state fMRI and single voxel 1H-MRS in a mouse model of chronic pain derived from bone cancer. Linear mixed model analysis of independent components revealed significant functional changes mostly in limbic but also cortical networks. These findings were reproducible across strains and mirror findings from clinical studies on chronic back pain patients. 1H-MRS in the affected ventral hippocampus yielded significant decreases in glutamate, myo-inositol and glycerylophosphorylcholine concentrations in tumor-animals as well as increased glutamine levels. Given the translatability, these readouts could potentially be used to evaluate novel treatments specifically for chronic pain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here