Abstract #3753

Metabolic and functional connectivity of the rat brain during resting state assessed by simultaneous [18F]FDG-PET/MR

Andre Thielcke¹, Mario Amend¹, Suril Gohel², Bharat Biswal², Bernd J. Pichler¹, and Hans F. Wehrl¹

¹Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University of Tuebingen, Tuebingen, Germany, ²Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States

Recent advancement in hardware and software has enabled researchers to study systems level neuroscience using simultaneous PET/MRI. In this study, simultaneous PET/MR was used to investigate resting state networks (RSN) in rats, comparing [18F]FDG PET vs. BOLD-fMRI. RSNs such as default mode network (DMN) have been shown to be disrupted in clinical populations. ICA and ROI-analysis was used to elucidate the complementary nature between PET/MR and visualize brain connectivity. ICA PET and MR data showed prominent RSNs. However, ROI-analysis illustrated different connectivity between network-involved areas. This work suggests the complimentary nature of metabolic connectivity mapping (Cometomics).

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