Abstract #3754

Decoupling flow effects on functional connectivity using R2* resting-sate fMRI

Venkata Veerendranadh Chebrolu¹, Brice Fernandez², Suresh E Joel¹, Bharath Sundar¹, Luca Marinelli³, Rakesh Mullick¹, Victor I Spoormaker⁴, Michael Czisch⁴, and Thomas K Foo³

¹GE Global Research, Bangalore, India, ²GE Healthcare, Munich, Germany, ³GE Global Research, Niskayuna, NY, United States, ⁴Max Planck Institute of Psychiatry, Munich, Germany

In this work we compare whole brain functional connectivity (FC) estimates from R2* resting-sate fMRI (rs-fMRI) with BOLD rs-fMRI. Thirty-two healthy subjects were imaged using three-echo multi-echo echo-planar-imaging (MEPI) under institutional guidelines. FC matrices based on structural and functional brain parcellation schemes were computed for individual BOLD echoes, R2* and M (initial magnetization approximated by BOLD signal at TE=0). Results tend to show that M might be helpful to decouple flow effects. Positive between network connectivity was observed in BOLD, M and R2* derived matrices. Anti-correlations observed between networks in BOLD and M were significantly lesser in R2* derived matrices.

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