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Abstract #3754

Decoupling flow effects on functional connectivity using R2* resting-sate fMRI

Venkata Veerendranadh Chebrolu1, Brice Fernandez2, Suresh E Joel1, Bharath Sundar1, Luca Marinelli3, Rakesh Mullick1, Victor I Spoormaker4, Michael Czisch4, and Thomas K Foo3

1GE Global Research, Bangalore, India, 2GE Healthcare, Munich, Germany, 3GE Global Research, Niskayuna, NY, United States, 4Max Planck Institute of Psychiatry, Munich, Germany

In this work we compare whole brain functional connectivity (FC) estimates from R2* resting-sate fMRI (rs-fMRI) with BOLD rs-fMRI. Thirty-two healthy subjects were imaged using three-echo multi-echo echo-planar-imaging (MEPI) under institutional guidelines. FC matrices based on structural and functional brain parcellation schemes were computed for individual BOLD echoes, R2* and M (initial magnetization approximated by BOLD signal at TE=0). Results tend to show that M might be helpful to decouple flow effects. Positive between network connectivity was observed in BOLD, M and R2* derived matrices. Anti-correlations observed between networks in BOLD and M were significantly lesser in R2* derived matrices.

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