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Abstract #3764

Altered gray matter volume, cerebral blood flow and functional connectivity in chronic stroke patients: a multi-modal MRI study

Peifang Miao1, Caihong Wang1, Peng Li1, Jingliang Cheng1, Dandan Zheng2, and Zhenyu Zhou2

1MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, People's Republic of, 2GE Healthcare MR Research, Beijing, China, People's Republic of

In order to investigate the cerebral plasticity in chronic stroke patients well-recovered in global motor function, 29 patients and 30 healthy subjects were recruited to undergo multi-modal MRI techniques. Group comparisons in gray matter volume(GMV), cerebral blood flow(CBF) and resting-state functional connectivity(rsFC) were assessed. Compared with healthy controls, patients exhibited increased GMV in contralesional supplementary motor area, increased CBFs in contralesional superior frontal gyrus and supramarginal gyrus, and increased rsFC in contralesional middle temporal gyrus. The results suggested cerebral structure plasticity, perfusion aberrant and functional reorganization coexist in well-recovered subcortical stroke patients, which may underlie functional recovery of stroke patients.

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