Abstract #3766

A Preliminary Study of Major Depressive Disorder Using Simultaneous PET/fMRI with Two MID Tasks in a Single Scan

Fuyixue Wang¹, Paul Hamilton², Brian Knutson², Ian Gotlib², Matthew Sacchet², Hershel Mehta², Christina Schreiner², Dawn Holley³, Fred Chin³, Bin Shen³, Greg Zaharchuk³, Mehdi Khalighi⁴, and Gary Glover³

¹Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, ²Department of Psychology, Stanford University, Stanford, CA, United States, ³Department of Radiology, Stanford University, Stanford, CA, United States, ⁴Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

The release of dopamine during reward tasks is modulated by major depressive disorder (MDD). In this study of MDD, we used simultaneous PET/fMRI to detect the neurochemical changes of dopamine and neurovascular activity through BOLD contrast during two sequential monetary incentive delay tasks in a single scan. Several modeling methods were proposed and evaluated for dynamic PET data. Six participants with MDD were studied. The results of the group analysis of PET and fMRI show significant effects of dopamine release in ventral striatum bilaterally, close to the nucleus accumbens, and significant BOLD signals in putamen bilaterally during reward tasks.

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