Abstract #3767

EEG-fMRI at 7T using simultaneous multislice 2D-EPI: safety and functional sensitivity at the single-subject level

João Jorge^1,2, Frédéric Grouiller³, Patricia Cotič⁴, Wietske van der Zwaag⁵, Patrícia Figueiredo², and Rolf Gruetter^1,6,7

¹École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²ISR-Lisboa/LARSyS/Department of Bioengineering, Instituto Superior Técnico, Lisbon, Portugal, ³Biomedical Imaging Research Center, University of Geneva, Geneva, Switzerland, ⁴Institute of Mathematics, Physics and Mechanics, Ljubljana, Slovenia, ⁵Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, ⁶Department of Radiology, University of Lausanne, Lausanne, Switzerland, ⁷Department of Radiology, University of Geneva, Geneva, Switzerland

The enhanced BOLD sensitivity available at 7T can bring significant advantages for EEG-fMRI studies, and the use of accelerated fMRI sequences such as SMS-EPI could further boost sensitivity. This work investigated whether SMS-EPI can be safely acquired with EEG at 7T, and whether the resulting sensitivity is favorable for combined EEG-fMRI approaches. The adopted SMS-EPI sequence (1.8mm isotropic resolution, whole-brain, TR_vol=1.57s) produced no temperature increases when combined with EEG. In a human, eyes-open/closed and resting-state activity patterns could be robustly detected in both modalites, and EEG-derived timecourses produced consistent BOLD predictions, even at a single-subject level with minimal spatial smoothing.

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