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Abstract #3767

EEG-fMRI at 7T using simultaneous multislice 2D-EPI: safety and functional sensitivity at the single-subject level

João Jorge1,2, Frédéric Grouiller3, Patricia Cotič4, Wietske van der Zwaag5, Patrícia Figueiredo2, and Rolf Gruetter1,6,7

1École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2ISR-Lisboa/LARSyS/Department of Bioengineering, Instituto Superior Técnico, Lisbon, Portugal, 3Biomedical Imaging Research Center, University of Geneva, Geneva, Switzerland, 4Institute of Mathematics, Physics and Mechanics, Ljubljana, Slovenia, 5Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 6Department of Radiology, University of Lausanne, Lausanne, Switzerland, 7Department of Radiology, University of Geneva, Geneva, Switzerland

The enhanced BOLD sensitivity available at 7T can bring significant advantages for EEG-fMRI studies, and the use of accelerated fMRI sequences such as SMS-EPI could further boost sensitivity. This work investigated whether SMS-EPI can be safely acquired with EEG at 7T, and whether the resulting sensitivity is favorable for combined EEG-fMRI approaches. The adopted SMS-EPI sequence (1.8mm isotropic resolution, whole-brain, TRvol=1.57s) produced no temperature increases when combined with EEG. In a human, eyes-open/closed and resting-state activity patterns could be robustly detected in both modalites, and EEG-derived timecourses produced consistent BOLD predictions, even at a single-subject level with minimal spatial smoothing.

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