Pharmacological Modulation of Static and Dynamic Functional Connectivity: a Simultaneous PET/MRI Study
Hsiao-Ying Wey1, R Matthew Hutchison2, Bruce R Rosen1, and Joseph B Mandeville1
1A. A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2Center for Brain Science, Harvard University, Cambridge, MA, United States
In this study, we present simultaneous PET/MRI
study with pharmacological challenges targeting the μ-opioid receptor system in
nonhuman primates to determine the effects of opioid drug on static and dynamic
functional connectivity. Mu-opioid receptor occupancy (quantified with PET) and
CBV-fMRI signals show dose-dependent reductions to opioid antagonist (naloxone)
challenges. Using brain regions showing PET signal changes as seeds, static FC
analysis shows an increase in local (within the seed region) and distal (motor
cortex) connectivity with putamen after naloxone. Dynamic FC patterns were also
modulated with naloxone as indicated by weaker pairwise correlations and larger
number of dynamic state transitions.
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