Abstract #3772

Pharmacological Modulation of Static and Dynamic Functional Connectivity: a Simultaneous PET/MRI Study

Hsiao-Ying Wey¹, R Matthew Hutchison², Bruce R Rosen¹, and Joseph B Mandeville¹

¹A. A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ²Center for Brain Science, Harvard University, Cambridge, MA, United States

In this study, we present simultaneous PET/MRI study with pharmacological challenges targeting the μ-opioid receptor system in nonhuman primates to determine the effects of opioid drug on static and dynamic functional connectivity. Mu-opioid receptor occupancy (quantified with PET) and CBV-fMRI signals show dose-dependent reductions to opioid antagonist (naloxone) challenges. Using brain regions showing PET signal changes as seeds, static FC analysis shows an increase in local (within the seed region) and distal (motor cortex) connectivity with putamen after naloxone. Dynamic FC patterns were also modulated with naloxone as indicated by weaker pairwise correlations and larger number of dynamic state transitions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.