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Abstract #3772

Pharmacological Modulation of Static and Dynamic Functional Connectivity: a Simultaneous PET/MRI Study

Hsiao-Ying Wey1, R Matthew Hutchison2, Bruce R Rosen1, and Joseph B Mandeville1

1A. A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2Center for Brain Science, Harvard University, Cambridge, MA, United States

In this study, we present simultaneous PET/MRI study with pharmacological challenges targeting the μ-opioid receptor system in nonhuman primates to determine the effects of opioid drug on static and dynamic functional connectivity. Mu-opioid receptor occupancy (quantified with PET) and CBV-fMRI signals show dose-dependent reductions to opioid antagonist (naloxone) challenges. Using brain regions showing PET signal changes as seeds, static FC analysis shows an increase in local (within the seed region) and distal (motor cortex) connectivity with putamen after naloxone. Dynamic FC patterns were also modulated with naloxone as indicated by weaker pairwise correlations and larger number of dynamic state transitions.

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